Nathan Hodges, Jr. and others founded the Oxford-Lafayette County branch of the NAACP in 1952 at Second Baptist Church originally under the title of the Lafayette County Improvement Club.
Churches played a part in the Civil Rights Movement, such as Second Missionary Baptist Church and Burns Methodist Church in Oxford.
Black Democrats during the Reconstruction period in Lafayette County included Joseph Taylor, Jim Nelson, Jack Carter, William Frierson, and Newton Chilton.